Mathematical Modelling of Alternative Pathway of Complement System
نویسندگان
چکیده
منابع مشابه
Quantitative Modeling of the Alternative Pathway of the Complement System
The complement system is an integral part of innate immunity that detects and eliminates invading pathogens through a cascade of reactions. The destructive effects of the complement activation on host cells are inhibited through versatile regulators that are present in plasma and bound to membranes. Impairment in the capacity of these regulators to function in the proper manner results in autoi...
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The alternative pathway, the phylogenetically oldest and most important activation pathway of the complement system, provides a highly efficient defence mechanism against invadingmicroorganisms and bacteria. Formation of C3b occurs spontaneously and continuously, while the further activation of this central component is tightly controlled by a large number of both soluble and membrane-bound reg...
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Alternative pathway amplification plays a major role for the final effect of initial specific activation of the classical and lectin complement pathways, but the quantitative role of the amplification is insufficiently investigated. In experimental models of human diseases in which a direct activation of alternative pathway has been assumed, this interpretation needs revision placing a greater ...
متن کاملMathematical Modelling of Pulmonary Edema
The excess accumulation of water in lung interstitial or alveolar is called pulmonary edema which is caused by factors that upset the normal Starling balance in micro-circulation. Pulmonary edema disturbs the alveolar gas exchanges which are normally regulated by the respiratory system. Mathematical modelling of pulmonary edema may help to predict the lung conditions and the mechanisms involved...
متن کاملMathematical Modelling of Pulmonary Edema
The excess accumulation of water in lung interstitial or alveolar is called pulmonary edema which is caused by factors that upset the normal Starling balance in micro-circulation. Pulmonary edema disturbs the alveolar gas exchanges which are normally regulated by the respiratory system. Mathematical modelling of pulmonary edema may help to predict the lung conditions and the mechanisms involved...
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ژورنال
عنوان ژورنال: Bulletin of Mathematical Biology
سال: 2020
ISSN: 0092-8240,1522-9602
DOI: 10.1007/s11538-020-00708-z